A Pass With No Number Led to a Retest: Crescent Bioresearch NAD+ Measures 92.7 EU per Vial Against a 350 EU Limit

The first endotoxin report on lot CBR-NAD-260411-001 recorded a pass with no measured value or threshold. A second report, from BTLabs, states 92.7 EU per vial against a threshold of 350 EU per vial and a lysate sensitivity of 0.05 EU/mL.

Albany, United States, October 22, 2026 -- ALBANY, N.Y., Oct. 22, 2026 -- Crescent Bioresearch, a supplier of laboratory compounds, has published a reissued NAD+ certificate of analysis for lot CBR-NAD-260411-001. The endotoxin result is 92.7 EU per vial, the threshold is 350 EU per vial, the lysate sensitivity is 0.05 EU/mL, and the lot passed. An earlier report on the same lot, from a different laboratory, also recorded a pass and printed none of those figures. The lot was retested at a second laboratory after the first did not supply a measured value.

Nadide (NAD+), also known as nicotinamide adenine dinucleotide, beta-NAD, Coenzyme I, Codehydrogenase I and diphosphopyridine nucleotide (DPN), CAS 53-84-9, is supplied by Crescent Bioresearch as NAD+ 1,000 mg for laboratory research.

Signed BTLabs endotoxin report for NAD+ 1,000 mg, lot CBR-NAD-260411-001, with the test date, threshold, result and determination highlighted. Result 92.7 EU per vial, threshold 350 EU per vial, lysate sensitivity 0.05 EU/mL, determination PASS. Kinetic turbidimetric LAL, USP 85.

The first report, June 30, 2026

The report listed two replicate lines for the bacterial endotoxins test, each reading "Pass." It gave an assay sensitivity of 0.05 EU/mL or less. A field headed "Endotoxin Threshold" also read "Pass." No endotoxin value appeared in any unit, and no numerical threshold appeared anywhere on the page. The laboratory was asked for the measured value and did not provide one. The lot was then sent to a second laboratory.

The second report, Oct. 9, 2026

BTLabs, an independent laboratory in West Palm Beach, Florida, tested the lot by the Limulus amebocyte lysate (LAL) test under USP General Chapter 85, Bacterial Endotoxins Test, after dissolving the vial in 2 mL. The page states a threshold of 350 EU per vial, a lysate sensitivity of 0.05 EU/mL, a result of 92.7 EU per vial and a determination of PASS. The vial holds 1,000 mg, so the result is 0.09 EU per milligram, and it stands at 26 percent of the threshold.

What a complete report contains

Endotoxin is lipopolysaccharide, a residue of Gram-negative bacteria that remains in a compound after the bacteria themselves are gone. The LAL test measures it in endotoxin units (EU). A complete report states the measured value, the threshold it was compared against and the sensitivity of the test. The June report stated only the last of the three, and the sensitivity describes the test rather than the vial.

What each report gives a research entity

From the June report, a research entity could learn that a test had been run and that someone had judged the lot acceptable. It could not learn how much endotoxin the vial contained, what limit had been applied or how far below that limit the lot sat. From the October report, a research entity can confirm the pass by comparing 92.7 with 350, convert the result into its own units, compare the lot with other lots and apply a limit of its own if its work calls for one. The second report is data. The first was a verdict.

A home inspection shows the same thing

A family is buying a house. The inspector walks through it and tells them the house passed inspection. They ask for the report, and the inspector does not provide one. The family has no way to know what was checked: the roof, the wiring, the foundation or the plumbing. They cannot see which areas came close to failing, or whether anything they care about was checked at all. A real inspection comes with a report that lists every area inspected, what was found and the standard it was held to. Without that report, "passed" is only the inspector's word.

The first endotoxin report on this NAD+ lot was that inspector. It said "Pass" and gave no measured value and no threshold. The number was requested and not supplied, and the lot was tested again at a second laboratory. The new certificate is the full report: 92.7 EU per vial against a threshold of 350 EU per vial.

The reissued certificate

The June report gave no measured value, so its pass could not be checked. The certificate was reissued with the October endotoxin page from BTLabs, which states the value, the threshold and the sensitivity. The NAD+ annotated endotoxin report from the second laboratory shows the four figures the June report lacked.

Endotoxin produces strong responses of its own in many experimental systems, even in small amounts. A research entity studying NAD+ needs to know how much is present, so that what it records can be attributed to the compound and not to the endotoxin.

"The laboratory that ran the first test had a number, because the test produces one," Crescent Bioresearch said. "The second report states it: 92.7 EU per vial against 350."

SOURCE DOCUMENTS

Bacterial Endotoxins Test report COA261889-001, issued by BTLabs, West Palm Beach, Florida, for NAD+ lot CBR-NAD-260411-001, tested Oct. 9, 2026, by LAL; the endotoxin report on the same lot issued June 30, 2026, by a third-party laboratory; USP General Chapter 85, Bacterial Endotoxins Test.

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